Organizational culture is the dominant value or habit that becomes the driving force for an organization. Values, thoughts, and symbols based on Islam that influence the norms of behavior, attitudes, habits, and habits of a person in various fields become the culture of Islamic organizations that are believed to be true. The fundamental problem in this research is that organizations do not understand what the dominant organizational culture is today, how effective the system users are with these cultural conditions, and whether the current level of effectiveness of the dominant culture follows Islamic values. Previous research shows the relationship between organizational culture and effectiveness, while this study adds new variables, and proves the relationship of organizational culture dominance model with system effectiveness based on Islamic values on practical contribution, and creates a new model on theoretical contribution. The research phase begins with finding the current dominant organizational culture using the Organizational Culture Assessment Instrument and the Cultural Values Framework Instrument. Next, look for the relationship between the current dominant organizational culture and the effectiveness of the system by using the Delone and Mclean Is Success Model. Then combine the second model based on Islamic values using Structural Equation Modeling (SEM) - Partial least square (PLS). The result of this research is that there is a relationship between the dominance of the current organizational culture and the effectiveness of information systems. This is because the dominant organization is a clan that is familial in reaching an agreement, commitment between members in communicating, increasing the intensity of members in using information systems, systems that are easy to reach and use, and the quality of information systems that are easy, effective, and accountable. Meanwhile, the dominance of organizational culture on the effectiveness of information systems based on Islamic values has not been fully proven. This means that the dominance of organizational culture on the effectiveness of the Islamic values information system still needs to be adjusted to the four indicators on the Islamic values variable showing the closeness of values.