During the operation of heated oil transportation pipeline, the shutdown is caused by some pipeline accidents or repairing. In order to ensure the safety operation of the pipeline, determine the temperature drop and restart pressure needed at different shutdown lasting time is important. This paper builds the heated oil pipeline shutdown and restart mathematic model based on heat transfer and fluid mechanics theory. The VB and MATLAB hybrid programming method which is on the basis of COM technical is utilized to develop heated oil pipeline shutdown and restart simulation software. The software application shows using of VB and MATLAB hybrid programming method can reduce the work of algorithm developing and enhance the reliability of heated oil pipeline shutdown and restart simulation software.