As we are in the world of emerging technologies people have more awareness about it especially Smartphone’s. Usage of Smartphone’s has been increased tremendously. Different operating systems (OS) are used in smart phones such as MAC OS, Android, and Windows OS etc. Most of the applications are run on their appropriate platform. Cloud is the simplest way to run certain application over cross platforms. Many cloud vendors are there who provides several kinds of applications and software which can be accessed by the users. In that Application Programming Interfaces (APIs) helps us to create a cloud application over the market. However there will be chances to occur Interoperability issues while users were working on a cross platforms. In order to overcome this issue a framework has been proposed named Mobile Cloud Middleware (MCM). MCM will recover the interoperability issues over multiple cloud services on mobile devices. Here in this paper we proposed effective result to solve the Interoperability issue by integrating Mobile Enterprise with MCM.