Hyperthermia is a thermal therapy for cancer treatment in which body temperature is exposed to elevated temperature of 40-42oC. Microwave ablation has a potential to be sensitive to changes in the dielectric tissue parameters which results in damaging abnormal tissues. In order to produce heat in the focused area microwave signals are adjusted in time, frequency and strength. The commonly used frequencies in microwave imaging systems are 415MHZ and 2.45GHZ which are transmitted from the antennas enclosing the relevant body part. This paper presents a highly efficient E-Shape micro strip patch microwave antenna operated at 2.45 GHz which can be used in various applicators for hyperthermia treatment system. The simulation is done on IE3D simulator. The results are compared at two feeding points 1 and 2 for the frequency 2.45GHZ. It gives return loss of -19.3dB, bandwidth of 6.2dB and the antenna efficiency of 92% for feeding point 1 which proves to be highly effective in communication.