Microwave-Induced Thermo-Acoustic Tomograp- phy (MITAT) has attracted more concerns in recent years in biomedical imaging field. It has both the high contrast of the microwave imaging and the high resolution of ultrasound imaging. As compared to optoacoustics, which uses instead a pulsed light for evoking optoacoustic response, thermo-aco- ustic imaging has the advantage of deeper tissue penetration, attaining the potential for wider clinical dissemination, especially for malignant tumors. In this paper, the induced thermo-acoustic wave propagating in a mimic biologic tissue is simulated by numeric method Pseudo-Spectrum Time Domain (PSTD). Due to the excellent performance in noise- depress and the stability for the fluctuation of the model parameters, Time Reversal Mirror (TRM) imaging technique is studied computationally for the simulative received therm- o-acoustic signals. Some thermo-acoustic objects with differ- ent initial pressure distribution are designed and imaged by TRM technique to represent the complex biologic tissue case in a random media. The quality of images generated by TRM technique based on PSTD method hints the potential of the MITAT technique.