The problem of the layout of NEMLC (National Economic Mobilization Logistics Center) is one of the most important long-term decision-making issues. The result of NEMLC’s layout directly impacts many aspects of mobilization, such as time, reliability, quality, efficiency, cost, and so on, consequently affects the effect of the mobilization. Reasonable NEMLC layout can bring people convenience in the daily life, reduce costs, and improve service efficiency and competitiveness. Poor NEMLC layout often brings a great deal of inconvenience and loss, and even leads to mobilization failure. Under the restriction of mobilization time, the paper establishes the layout model that one or more mobilization logistics centers provide the material to the mobilization demanding place. The mobilization goods or service can reach the demanding place to carry into mobilization execution within the given time, and the number of the built NEMLCs is the least.