Naveen. N.; Nagaraj. G. Cholli

Enhancing Early Alzheimer's Disease Detection: Leveraging Pre-trained Networks and Transfer Learning

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Author(s)

1. Department of Computer Science & Engineering, M. S. Ramaiah University of Applied Sciences, Visvesvaraya Technological University, Belagavi, 590018, India

2. Department of Information Science & Engineering, RV College of Engineering, Visvesvaraya Technological University, Belagavi, 590018, India

* Corresponding author.

DOI: https://doi.org/10.5815/ijisa.2024.01.05

Received: 19 Sep. 2023 / Revised: 26 Oct. 2023 / Accepted: 7 Dec. 2023 / Published: 8 Feb. 2024

Index Terms

VGG, Inception, Residual Network (ResNet), Convolutional Neural Network (CNN), Transfer Learning (TL), Magnetic Resonance Imaging (MRI), Deep Neural Networks (DNN)

Abstract

Alzheimer's Disease (AD) is a progressive neurodegenerative disorder affecting millions worldwide. Early and accurate AD detection is crucial for timely intervention and improving patient outcomes. Lately, there have been notable advancements in using deep learning approaches to classify neuroimaging data associated with Alzheimer's disease. These methods have shown substantial progress in achieving accurate classification results. Nevertheless, the concept of end-to-end learning, which has the potential to harness the benefits of deep learning fully, has yet to garner extensive focus in the realm of neuroimaging. This is attributed mainly to the persistent challenge in neuroimaging, namely the limited data availability. This study employs neuroimages and Transfer Learning (TL) to identify early signs of AD and different phases of cognitive impairment. By employing transfer learning, the study uses Magnetic Resonance Imaging (MRI) images from the Alzheimer's Disease Neuroimaging (ADNI) database to classify images into various categories, such as Cognitively Normal (CN), Early Mild Cognitive Impairment (EMCI), Mild Cognitive Impairment (MCI), Late Mild Cognitive Impairment (LMCI), and Alzheimer's Disease (AD). The classification task involves training and testing three pre-trained networks: VGG-19, ResNet-50, and Inception V3. The study evaluates the performance of these networks using the confusion matrix and its associated metrics. Among the three models, ResNet-50 achieves the highest recall rate of 99.25%, making it more efficient in detecting the early stages of AD development. The study further examines the performance of the pre-trained networks on a class-by-class basis using the parameters derived from the confusion matrix. This comprehensive analysis provides insights into how each model performs for different classes within the AD classification framework. Overall, the research underscores the potential of deep learning and transfer learning in advancing early AD detection and emphasizes the significance of utilizing pre-trained models for this purpose.

Cite This Paper

Naveen. N., Nagaraj. G. Cholli, "Enhancing Early Alzheimer's Disease Detection: Leveraging Pre-trained Networks and Transfer Learning", International Journal of Intelligent Systems and Applications(IJISA), Vol.16, No.1, pp.52-69, 2024. DOI:10.5815/ijisa.2024.01.05

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