The paper presents the technology of gene expression profiles filtering based on the wavelet analysis methods. A structural block-chart of the wavelet-filtering process, which involves concurrent calculation of Shannon entropy for both the filtered data and allocated noise component is proposed. Simulation of the wavelet-filtering process was performed with the use of orthogonal and biorthogonal wavelets on different levels of wavelet decomposition and with the use of various values of the thresholding coefficient. Result of the simulation has allowed us to propose the technology to determine the optimal parameters of the wavelet filter based on complex analysis of the filtered data and allocated noise component.